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New Antibodies
We are continuously adding new antibodies to our portfolio of cancer and
neurological research reagents.
MUB0101
Alpha-Internexin/NF66 Monoclonal Antibody
Alpha-internexin is a Class IV intermediate filament originally
discovered as it copurifies with other neurofilament subunits (1). It is
expressed only in neurons and in large amounts early in neuronal
development, but is down-regulated in many neurons as development
procedes. Many classes of mature neurons contain a-internexin in
addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is
the only neurofilament subunit expressed. Antibodies to a-internexin are
therefore unique probes to study and classify neuronal types and follow
their processes in sections and in tissue culture. In addition recent
studies show a marked up-regulation of a-internexin during neuronal
regeneration. Recently Trojanowski, Lee and coworkers used this antibody
to show that a-internexin is an abundant component of the inclusions of
neurofilament inclusion body disease, a serious human neurodegenerative
disorder.
MUB1801 Anti-Trp-p8 Polyclonal Antibody
A novel gene, trp-p8 has an expression pattern within normal human
tissues that is mostly restricted to prostate epithelial cells. Trp-p8
mRNA expression is at moderate levels in normal prostate tissue and
appears to be elevated in prostate cancer. Notably, trp-p8 mRNA is also
expressed in a number of nonprostatic primary tumors of breast, colon,
lung, and skin origin, whereas transcripts encoding trp-p8 were hardly
detected or not detected in the corresponding normal human tissues.
MUB0600 Anti-FBG3 (F Box 3) Polyclonal Antibody
MUB0601 Anti-FBG4 (F Box 4) Polyclonal Antibody
F-box proteins, a critical component of the evolutionary conserved
ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit
substrates for ubiquitination and consequent degradation through their
specific protein-protein interaction domains. FBG genes are expressed in
a limited number of human tissues including kidney, liver, brain and
muscle tissues.
MUB0800 Anti-Humanin Polyclonal Antibody
A gene, Humanin, encodes a short polipeptide and abolishes death of
neuronal cells caused by multiple different types of familial
Alzheimer's disease genes and by Abeta amyloid, without effect on death
by Q79 or superoxide dismutase-1 mutants. This polypeptide serves as a
molecular clue for the development of new therapeutics for Alzheimer's
disease targeting neuroprotection.
MUB1600 Anti-Rattin (Humanin-like) Polyclonal Antibody
A novel rat gene, Rattin, encodes a peptide homologous to Humanin, a
secreted peptide that specifically protects against neuronal cell death
induced by beta-amyloid peptide (Ab) or by mutations causing early-onset
familial Alzheimer's disease. The rat gene, Rattin, encodes a peptide of
38 residues (15 residues longer than Humanin) showing 73% identity in
the conserved region to Humanin.
MUB1000 Anti-Ku80 Polyclonal Antibody
MUB1001 Anti-Ku80 Polyclonal Antibody
Telomere length maintenance, an activity essential for chromosome
stability and genome integrity, is regulated by telomerase- and
telomere-associated factors. The DNA repair protein Ku (a heterodimer of
Ku70 and Ku80 subunits) associates with mammalian telomeres and
contributes to telomere maintenance. The Ku heterodimer functions at two
kinds of DNA ends: telomeres and double-strand breaks. The role that Ku
plays at these two classes of termini must be distinct, because Ku is
required for accurate and efficient joining of double-strand breaks
while similar DNA repair events are normally prohibited at chromosome
ends.
MUB1501 Anti-PARK7 (DJ-1) Polyclonal Antibody
Four chromosomal loci (PARK2, PARK6, PARK7, and PARK9) associated with
autosomal recessive, early onset parkinsonism are known. Positional
cloning within the refined PARK7 critical region recently identified
mutations in the DJ-1 gene in PARK7-linked families. Mutations in the
PARK7/DJ-1 gene cause autosomal-recessive Parkinsons disease.
MUB0500 Anti-EAPII Polyclonal Antibody
ETS proteins constitute a family of conserved sequence-specific
DNA-binding proteins and function as transcription factors with roles in
differentiation, lymphoid cell development, invasiveness and
angiogenesis. A novel ETS1 interacting protein designated as
ETS1-associated protein II (EAPII) interacts with ETS1 and other ETS
proteins (ETS2 and FLI1) and is a novel ETS1 modulator.
MUB1309 Anti-NKX3.1 Polyclonal Antibody
NKX3.1 is a homeobox gene which exhibits prostate and testis specific
expression. Loss of NKX3.1 expression has been implicated in prostate
development and tumorigenesis. NKX3.1 expression is dramatically
down-regulated in testicular cancer of germ cell origin. Results suggest
that NKX3.1 is essential for normal testis function and that its loss of
expression is highly associated with the invasive phenotype of
testicular germ cell tumors.
MUB2000 WW domain-containing oxidoreductase (WWOX) Polyclonal
Antibody
WW domain-containing oxidoreductase WWOX, also known as WOX1 or FOR, is
a proapoptotic protein and a tumor suppressor gene. Because mutation or
deletion in the coding region of WWOX is rarely found, it is speculated
that the appearance of aberrant transcripts affects progression of many
cancers. In addition, protein levels of WWOX, its Tyr33-phosphorylated
form, and WOX2 are significantly down-regulated in the neurons of
Alzheimer's hippocampi.
MUB1800 Anti-Tet Repressor Polyclonal Antibody
The Tet repressor protein (TetR) regulates transcription of a family of
tetracycline resistance determinants in Gram-negative bacteria. The Tet
system is the most widely used regulatory system for conditional gene
expression in eukaryotic cells. TetR can be used for that purpose in
some organisms without further modifications. In mammals and in a large
variety of other organisms, however, eukaryotic transcriptional
activator or repressor domains are fused to TetR to turn it into an
efficient regulator.
For information about these and other antibodies MUbio is marketing,
please refer to our
Product Information page
or move directly to our Antibody-shop®.
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