MONOCLONAL ANTIBODIES TO CYTOKERATINS  

Clone

 Specificity Applicability

Species
cross-
reactivity

Ig-
Isotype

Ref.
RCK103 Basal Cell Cytokeratin

A broadly cross-reacting antibody staining basal cells in combined and stratified epithelial tissues.

 F, C, FC,WB human, quail, chicken, rat, rabbit, hamster, canine, swine, guinea pig mouse
IgG1		 [1,18, 24]
6B10 Cytokeratin 4

Specifically recognizes cytokeratin 4 in non-cornified squamous epithelia, including cornea and transitional epithelium.

 F, WB, FC human, feline, canine mouse
IgG1		 [21, 22, 24]
RCK102 Cytokeratins 5
and 8

A  broadly reacting cytokeratin antibody recognizing virtually all epithelial tissues and carcinomas.
This antibody reacts particularly well in paraffin embedded tissue.

 F, C, P, FC, WB human, mouse, rat, hamster, rabbit,canine, swine mouse
IgG1		 [1- 5, 24]
RCK105 Cytokeratin 7

Reacts with a subgroup of glandular epithelia and their tumors, as well as transitional epithelium and transitional carcinoma.

 F, C, FC, WB human, mouse, rat, hamster, canine, swine mouse
IgG1		 [1- 5, 24]
OVTL 12/30

Cytokeratin 7

Reacts with a subgroup of glandular epithelia and their tumors, as well as transitional epithelium and transitional carcinoma.
This antibody reacts particularly well in paraffin embedded tissue.

 F, C, P, FC, WB

exclusively human

 

mouse
IgG1

 

 [13-17]
H1 Cytokeratin 8 C, F, P, FC, WB human IgG1
M20

Cytokeratin 8

Reacts with glandular epithelial cells of  the digestive, respiratory, and urogenital tracts, endocrine and exocrine cells and mesothelial cells, as well as adenocarcinomas originating from them.

 F, C, FC, WB human, mouse

mouse
IgG1 

 

 [1, 3]
RKSE60

Cytokeratin 10

Reacts with keratinizing stratified epithelia and in differentiated areas of highly differentiated squamous cell carcinomas.

 F, C, WB, FC  human, mouse, rat, canine mouse
IgG1		 [3, 6, 24]
DE-K10

Cytokeratin 10

Reacts with keratinizing stratified epithelia and in differentiated areas of highly differentiated squamous cell carcinomas.
This antibody reacts particularly well in paraffin embedded tissue.

 F, C, P, FC, WB human, feline, canine mouse
IgG1		 [19, 20, 24]
DE-K13 Cytokeratin 10/13

Reacts with non-keratinizing stratified epithelia and transitional epithelium,as well as carcinomas derived from these tissues.
This antibody reacts particularly well in paraffin embedded tissue where it only recognises  cytokeratin 13.

 F, C, P, FC, WB human, feline mouse
IgG2a		 [20]
1C7 Cytokeratin 13

Reacts with non-cornified squamous epithelia, except cornea.

F, WB human mouse IgG2a [21- 23]
RCK107 Cytokeratin 14

Reacts with basal cell compartments of stratified and combined epithelia.

F, C, FC, WB human, rat, canine, swine mouse
IgG3		 [7, 8, 24]
SPK-14

Cytokeratin 14

Reacts with basal cell compartments of stratified and combined epithelia. This antibody reacts particularly well in paraffin embedded tissue.

 F, C, FC, WB human, feline mouse
IgG1		 [20]
E3 Cytokeratin 17

 

 C, F, P, FC, WB human, rat IgG2b
RGE53 Cytokeratin 18

Reacts with glandular epithelial cells of the digestive, respiratory, and urogenital tracts, endocrine and exocrine cells and mesothelial cells, as well as adenocarcinomas originating from them.

F, C, WB, FC human, mouse, rat, hamster, rabbit, chicken, canine, swine mouse
IgG1		 [3 - 6, 9, 24]
RCK106 Cytokeratin 18

Reacts with glandular epithelial cells of the digestive, respiratory, and urogenital tracts, endocrine and exocrine cells and mesothelial cells, as well as adenocarcinomas originating from them.

F, C, FC, WB exclusively human mouse
IgG1		 [1, 4, 5, 10]
DE-K18

Cytokeratin 18

Reacts with glandular epithelial cells of the digestive, respiratory, and urogenital tracts, endocrine and exocrine cells and mesothelial cells, as well as adenocarcinomas originating from them.
This antibody reacts particularly well in paraffin embedded tissue.

 F, C, P, FC, WB human, feline, canine mouse
IgG1		 [20, 24]
RCK108 Cytokeratin 19

Reacts with glandular-type epithelia and most carcinomas.
Does not react with hepatocytes and hepatocellular carcinoma.
This antibody reacts particularly well in paraffin embedded tissue.

 F, C, FC, P, WB human mouse
IgG1		 [11, 12]

 
C = cytological material
F = frozen sections
FC = flow cytometry
P = paraffin embedded sections
WB = Western blotting