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Whereas
for microtubules and microfilaments involvement in various processes such as cell
division, cell locomotion, cellular polarity, anchorage and protoplasmic streaming has
been demonstrated, the function of intermediate filaments has not yet been elucidated,
although a role in the maintance of cell integrity has become likely. Antibodies to
specific cytoskeketal proteins are widely applicable in cell biology. Antibodies to
intermediate filament proteins furthermore allow the differentiation of the major classes
of tissues and their malignancies and have
therefore become an important tool in tumor
pathology.
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