CELL CYCLE RELATED ANTIBODIES
The life cycle of
a eukaryotic cell consists of various phases, two of which can easily be identified.
Firstly, during mitosis (M-phase), in which the cell divides into two identical daughter
cells, chromosome condensation and spindle formation are microscopically visible.
Secondly, in S-phase the DNA of a cell is replicated, a process that can be detected using
biochemical techniques. In between the M- and S-phase two gap phases occur: the G1-phase,
the gap between mitosis and the start of DNA replication, and G2-phase, the gap
between completion of DNA replication and the onset of mitosis. From G1-phase a
cell can leave the cell cycle and enter G0, a ‘quiescent’ phase.
Regulation of the cell cycle predominantly occurs at three major control points, which
govern the transition from G0 to G1, from G1 to S and
from G2 to M-phase.
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